Chromatin structure and the inheritance of epigenetic information
نویسندگان
چکیده
منابع مشابه
Inheritance of epigenetic chromatin silencing.
Maintenance of alternative chromatin states through cell divisions pose some fundamental constraints on the dynamics of histone modifications. In this paper, we study the systems biology of epigenetic inheritance by defining and analyzing general classes of mathematical models. We discuss how the number of modification states involved plays an essential role in the stability of epigenetic state...
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Enhancer-blocking insulators are DNA elements that disrupt the communication between a regulatory sequence, such as an enhancer or a silencer, and a promoter. Insulators participate in both transcriptional regulation and global nuclear organization, two features of chromatin that are thought to be maintained from one generation to the next through epigenetic mechanisms. Furthermore, there are m...
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The genome of eukaryotic organisms is compacted in the nucleus in a manner that allows transmission of the genetic material between generations and access of the replication and transcription machinery to the DNA. Expression or repression of specific genes is accompanied by alterations in the local chromatin carried out by DNA methyl transferases, histone modifying enzymes, ATP-dependent chroma...
متن کاملChromatin resetting mechanisms preventing transgenerational inheritance of epigenetic states
Epigenetic regulation can be altered by environmental cues including abiotic and biotic stresses. In most cases, environmentally-induced epigenetic changes are transient, but in some cases they are maintained for extensive periods of time and may even be transmitted to the next generation. However, the underlying mechanisms of transgenerational transmission of environmentally-induced epigenetic...
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ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2010
ISSN: 1471-0056,1471-0064
DOI: 10.1038/nrg2752